BLC

    Ingredient deep dive

    Encapsulated Endonuclease

    Also seen as: DNA repair enzyme, photolyase-class enzyme
    All ingredients

    What it does

    A DNA repair enzyme delivered in a liposomal capsule to support the skin's natural repair of UV-induced damage at the cellular level.

    Best for

    Mature skin, sun-exposed skin, and longevity-focused anti-aging routines.

    The full picture

    Endonucleases are enzymes that cut DNA at specific points to support the cell's natural repair of damage. UV radiation creates pyrimidine dimers and other DNA lesions in skin cells, which accumulate over time and contribute to visible aging. Topical endonuclease products encapsulate the enzyme in liposomes to help it survive long enough to reach living skin cells. The category is relatively new and the strongest research is on photolyase-class enzymes. Used in Medik8 Advanced Pro-Collagen+ Peptide Cream as part of the brand's longevity-positioning.

    Evidence

    Topical DNA repair enzymes have been shown to reduce markers of UV damage in skin cells in laboratory and clinical studies.

    Read the source: PubMed: topical DNA repair enzymes ->