What it does
A regenerative ingredient derived from salmon DNA fragments, used to support hydration and the look of skin repair and rejuvenation.
Best for
Dull, tired, or aging skin seeking a rejuvenation and hydration boost. Strongest evidence is for in-clinic injectable use.
What is PDRN?
PDRN, short for polydeoxyribonucleotide, is a regenerative ingredient made from purified salmon DNA fragments. It is used to support hydration and the look of skin repair and rejuvenation, and it belongs to the polynucleotide family.
It became popular first in esthetic clinics, and it is now appearing in topical serums.
Does PDRN work in skincare?
PDRN has strong evidence as an injectable skin booster, and topical versions are a promising but newer, less-proven category.
A systematic review found polynucleotides deliver rejuvenation and skin-quality benefits in esthetic medicine, with the strongest data for injectable use.
In a topical serum, such as the PDRN serums from budget ranges like The Inkey List, expect hydration and a smoother-looking finish rather than the results of an in-clinic treatment. Set expectations at the appearance of fresher, more hydrated skin.
Who should use PDRN?
Topical PDRN suits anyone curious about a hydrating, rejuvenation-focused serum. For a stronger, evidence-backed result, the injectable form is a professional treatment, not a cream.
Evidence
Polynucleotides (the PDRN family) show rejuvenation and skin-quality benefits in esthetic medicine, with the strongest evidence for injectable skin boosters.
Read the source: Systematic review: the effectiveness of polynucleotides in esthetic medicine (2025) ->
