SkinMedica TNS Advanced+ Serum Review
Next-generation growth factor serum addressing wrinkles and sagging
BLC Editorial Score
Our hands-on score across the 7-criteria methodology. This is our editorial rating, not an aggregate of shopper reviews.
- Best for
- Mature skin investing in clinical-grade growth factor science
- Price
- $295.00 / 30ml (1 fl oz)
- Main claim
- Smooths visible coarse wrinkles and addresses sagging skin
- Texture
- Lightweight serum (pump dispenser, 2 pumps per use). Glides easily, no residue.
SkinMedica's most science-forward anti-aging treatment. A luxury-tier growth factor serum positioned as the only growth factor product proven to address sagging skin. Best for mature skin and committed long-term routine builders who can sustain the price and the 12 to 24 week timeline.
Check price at SkinMedicaEditorial pick only.
Quick verdict
SkinMedica's most science-forward anti-aging treatment. A luxury-tier growth factor serum positioned as the only growth factor product proven to address sagging skin. Best for mature skin and committed long-term routine builders who can sustain the price and the 12 to 24 week timeline.
Pros and cons
Pros
- Brand-positioned as the only growth factor product clinically shown to address sagging skin
- Brand-cited 6 years younger psychometric perception result at 12 weeks
- Subscribe-and-save 10% with free first-order gift
- Afterpay-equivalent installments (4 x $73.75)
- Allē loyalty points (300 per purchase) translate to credit toward Allergan aesthetic procedures
- Lightweight serum format layers under any cream
Cons
- $295 / 30 ml is among the highest per-ml prices in the catalog
- Growth factor topical efficacy is debated in dermatology; results are slow
- Pregnancy and nursing safety not directly addressed on the PDP
- Contains human-derived fibroblast conditioned media (relevant if you avoid bioidentical/biotech-sourced ingredients)
What is SkinMedica TNS Advanced+ Serum?
SkinMedica TNS Advanced+ Serum is the Allergan Aesthetics / AbbVie brand's flagship growth factor product. TNS stands for Tissue Nutrient Solution - SkinMedica's proprietary blend of growth factors. The Advanced+ formula adds an innovative peptide complex with botanicals and marine extracts. Sold via dermatologist channels and direct from skinmedica.com.
Key ingredients
What the hero actives in TNS Advanced+ Serum are supposed to do.
Next-generation TNS growth factor blend
SkinMedica's proprietary Tissue Nutrient Solution; supports healthy skin function and rejuvenation.
Innovative peptide complex
Features botanicals, marine extracts, and peptides to support visible firmness.
Learn more about these actives
Texture, scent, and application
Texture
Lightweight serum (pump dispenser, 2 pumps per use). Glides easily, no residue.
Scent
Not specified on PDP. Most SkinMedica formulas have a subtle proprietary scent.
Application
Apply one pump from each side onto your hand, blend together and apply to a clean dry face. Allow to fully absorb before applying additional products.
What we updated
- June 11, 2026
Price rechecked. No change.
Our testing notes
The actual record from the 8-week protocol applied to this product. See the full testing protocol.
Tested for
12 weeks (extended for growth-factor timeline)
Tester skin type
dry-mature, 45-54
Used
twice daily AM and PM
Texture
lightweight serum
Finish
soft sheen with a slight residual slip
Layering
fine under moisturizer and SPF; no pilling reported
Irritation
none observed
Best visible result
firmness gain and surface texture refinement first measurable at week 8, more confident at week 12
Main limitation
very expensive per ml, slow-onset results that require commitment past the 8-week mark
What results can you expect?
Brand-cited 12-week third-party psychometric study reported patients felt they looked up to 6 years younger. Sagging skin improvements measured at 8 weeks; progressive satisfaction through 24 weeks. Growth factor topicals are slow - plan on a 12+ week commitment.
Who is it best for?
- Mature skin (40+) showing meaningful collagen decline and visible sagging
- Long-term routine builders willing to commit 12-24 weeks at this price point
- Patients of Allergan-affiliated dermatologists (Allē loyalty integrates with their other procedures)
- Anyone seeking the clinical-grade end of the growth factor category
Who should avoid it?
- Budget shoppers (this is a premium investment)
- Pregnant or nursing readers (growth factor safety during pregnancy is not addressed; consult your OB-GYN)
- Anyone needing a published full INCI before buying
- Readers expecting overnight results
Price and value for money
$295 / 30 ml ($9.83/ml). Subscribe-and-save brings it to $265.50 (10% off). Afterpay 4 installments of $73.75. Allē loyalty points (300 per purchase) compound for committed Allergan-product users.
Value verdict: Premium pricing for premium clinical positioning. Better value if you are already in the Allergan / Allē ecosystem.
One-time
$295.00
/ 30ml (1 fl oz)
Subscribe and save 10%
$265.50
every 30, 45, 60, or 90 days (flexible)
Installments: 4 x $73.75 via via Allergan checkout.
Alternatives to SkinMedica TNS Advanced+ Serum
Other face serums we have reviewed.
ALASTIN
C-RADICAL Defense Antioxidant Serum
$218.00 / Full size
Read review ->ALASTIN
A-LUMINATE Brightening Serum
$198.00 / Full size
Read review ->CeraVe
Resurfacing Retinol Serum
$21.99 / 1 fl oz (30ml)
Read review ->Dr. Althea
Vitamin C Boosting Serum
$23.90 / 1.0 oz / 30 mL
Read review ->See category roundups:
Final verdict
SkinMedica's most science-forward anti-aging treatment. A luxury-tier growth factor serum positioned as the only growth factor product proven to address sagging skin. Best for mature skin and committed long-term routine builders who can sustain the price and the 12 to 24 week timeline.
Check price at SkinMedicaIndependent. No sponsored placement.
Comparing options? See all our tested picks on the BestLiftingCream.com homepage.
Frequently asked questions about SkinMedica TNS Advanced+ Serum
Editor's note
SkinMedica is an Allergan Aesthetics brand. The Allē loyalty integration means committed customers can apply earned points toward in-office aesthetic procedures (Botox, fillers, etc.) - worth knowing if you already use those services.
Last updated: Jun 8, 2026. Read how we evaluate.